A high lactate level in the blood means that the disease or condition a person has is causing lactate to accumulate. In general, a greater increase in lactate means a greater severity of the condition. When associated with lack of oxygen, an increase in lactate can indicate that organs are not functioning properly.
What is considered a high lactic acid level?
A level > 4 mmol/L defines lactic acidosis3, a level high enough to tip the acid-base balance, which may result in a serum pH < 7.35 in association with metabolic acidosis. Lactate can be measured from both venous and arterial blood.
What is a critical lactate level?
The normal blood lactate concentration in an unstressed patient is 0.5-1 mmol/L. Patients with critical illness can be considered to have normal lactate concentrations of less than 2 mmol/L.
What is a normal lactate level?
Normal lactate range is less than 2.3 mmol/L. At enrollment, patients in the second quartile (1.4 < lactate < 2.3 mmol/L) had significantly increased mortality and organ dysfunction compared with patients who had lactate ≤ 1.4 mmol/L (quartile 1) (P < 0.0001).
How high can lactate levels go?
Elevated lactate is not clearly and universally defined but most studies use cut-offs between 2.0 and 2.5 mmol/L7 whereas “high” lactate has been defined as a lactate level > 4mmol/L in a number of studies. Furthermore, the “normal value” may vary depending on the assay used.
What diseases cause high lactic acid?
The most common cause of lactic acidosis is severe medical illness in which blood pressure is low and too little oxygen is reaching the body’s tissues.
Certain diseases can also cause the condition, including:
- Cyanide poisoning.
- Kidney failure.
- Respiratory failure.
- Sepsis (severe infection)
What happens if your lactic acid is high?
Higher-than-normal lactic acid levels can lead to a condition called lactic acidosis. If it’s severe enough, it can upset your body’s pH balance, which indicates the level of acid in your blood. Lactic acidosis can lead to these symptoms: muscle weakness.
Why is high lactate bad?
Very high levels of lactic acid cause a serious, sometimes life-threatening condition called lactic acidosis. Lactic acidosis can also occur in a person who takes metformin (Glucophage) to control diabetes when heart or kidney failure or a severe infection is also present.
What does a lactate of 7 mean?
An elevated lactate is associated with increased mortality.1-7 If the lactate is cleared it is associated with. better outcome.8-12 Lactate is the best means to screen for occult severe sepsis (occult sepsis is when.
How do you treat high lactate levels?
Increasing oxygen to the tissues and giving IV fluids are often used to reduce lactic acid levels. Lactic acidosis caused by exercising can be treated at home. Stopping what you’re doing to hydrate and rest, often helps.
When do you order lactate?
The test may be ordered when a person has signs and symptoms that a healthcare practitioner suspects are related to sepsis, shock, heart attack, severe congestive heart failure, kidney failure, or uncontrolled diabetes. The lactate test may be initially ordered with other tests to help evaluate a person’s condition.
What does lactate do in the body?
When the body has plenty of oxygen, pyruvate is shuttled to an aerobic pathway to be further broken down for more energy. But when oxygen is limited, the body temporarily converts pyruvate into a substance called lactate, which allows glucose breakdown—and thus energy production—to continue.
Can alcohol cause high lactate levels?
Significant elevations of blood lactate are uncommon in acute ethanol intoxication. In patients with ethanol intoxication who are found to have lactic acidosis, other etiologies for the elevated lactate level should be considered.