How safe and effective is Ondansetron for nausea and vomiting in pregnancy?

Q: How safe and effective is ondansetron for nausea and vomiting in pregnancy? Evidence-based answer: oral ondansetron is more effective than a combination of pyridoxine and doxylamine for outpatient treatment of nausea and vomiting in pregnancy (strength of recommendation [SOR]: B, randomized controlled trial [RCT]).

Can a pregnant woman take ondansetron for nausea?

Zofran is approved by the Food and Drug Administration (FDA) for use to fight off nausea related to chemotherapy. It is not currently approved by the FDA for morning sickness. Even so, most studies show that ondansetron is safe to use during the first trimester when most women experience morning sickness.

Is ondansetron safe in early pregnancy?

Ondansetron. Although ondansetron has limited safety data in pregnancy, it is often prescribed for women with hyperemesis gravidarum. It is not recommended as first-line therapy, especially in the first trimester of pregnancy. Ondansetron commonly causes constipation, which may already be a problem in pregnancy.

How much ondansetron is safe during pregnancy?

The dose of Zofran for hyperemesis gravidarum requiring hospitalization is a maximum of 10 milligrams via intravenous therapy (IV) every 8 hours. More typical pregnancy nausea is managed by a much lower oral dose — 4 to 8 mg every 8 hours.

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Can ondansetron cause miscarriage?

There are no concerns that ondansetron use in pregnancy affects the chance of miscarriage, stillbirth, preterm delivery or low infant birth weight.

Is ondansetron safe in pregnancy NHS?

The Royal College of Obstetricians and Gynaecologists recommends the use of ondansetron should be limited to patients who are not adequately managed on the first- and second-line anti-emetics above, and preferably used after the first trimester of pregnancy.

What is the best anti-nausea medication?

Best anti-nausea medications

Best anti-nausea medications
Compro (prochlorperazine) Rx & OTC FDA has not classified this drug
Ativan (lorazepam) Rx Positive evidence of risk
Dramamine (dimenhydrinate) Rx & OTC No evidence of risk – Category B
Bonine (meclizine) Rx & OTC No evidence of risk

Is ondansetron 8 mg safe during pregnancy?

Although not specifically approved by the FDA for the management of nausea and vomiting during pregnancy, ondansetron is now commonly used during pregnancy.

Is Zofran safe at 8 weeks pregnant?

A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus.

What pregnancy category is ondansetron?

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

What are the side effects of ondansetron?

Ondansetron may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache.
  • constipation.
  • weakness.
  • tiredness.
  • chills.
  • drowsiness.
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How often can I take Zofran 4 mg for nausea?

The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor.